Just think...pregnant women get levels as high as 75,000 pg/ml and aren't dying left and right. Their risks of having a blood clot is less than 0.2%. Breast cancer incidence has been inversely associated with pregnancy.
Men with prostate cancer, aged 49-91, with levels up to 700 pg/ml, were found to not have any cardiovascular complications or thrombosis from estradiol treatment given non-orally.
Food for thought...