Here is a graph showing that it really matters:
https://www.susans.org/forums/index.php/topic,186946.msg1665088.html#msg1665088With sublingual intake levels rise fast, and drop after a few hours...
Sublingual intake bypasses the liver and thus causes less clotting factors and less strain on the liver.
So spreading the daily dose in a few small doses might be a good idea.
Otherwise there might be a menopausal like effect a few times a day which might affect mood.
The same is true for swallowing pills if times of intake are far away from each other, like once a day.
For sublingual intake micronized bioidentical estrogen like estrace or generics are ideal.
Some poeple are sensitive some people do not feel much of an effect on mood.
In case of sensitivity there are small dose pills available, or pills might be broken in half.
You might talk all of this through with your doc.
*hugs*