Finally, Finally, Finally Saw My Endo Today!

[arice]

Phoenix, you are so damned close! Gather your evidence and hang in there.

This!

Sent from my SM-G870W using Tapatalk

[KayXo]

the FDA states that testosterone therapy can cause DVTs.

"The risk of venous blood clots is already included in the labeling of testosterone products as a possible consequence of polycythemia, an abnormal increase in the number of red blood cells that sometimes occurs with testosterone treatment. Because there have been postmarket reports of venous blood clots unrelated to polycythemia, FDA is requiring a change to drug labeling of all testosterone products to provide a more general warning regarding venous blood clots and to ensure this risk is described consistently in the labeling of all approved testosterone products."

"A possible consequence" is SPECULATION, not proven.

Reports of blood clots in men who took testosterone does not establish causation. It could well be that these men would have had blood clots anyways, even if they had not taken testosterone. How many of these reports are there anyways? I don't know. Take this warning and take the other studies on transmen and cismen. The doctor's decision should be based on the overall evidence and the benefits vs risks to you of taking testosterone.

Also, if testosterone causes DVT, wouldn't cismen would be at greater risk of developing this throughout their lives? Is this actually the case? Are clots more prevalent in cismen?

This matter should be looked at critically and objectively.

But I think they're talking about commercialized testosterone for cis men, not men like me.

The only difference I see is age, because cismen are usually older and thus more prone to DVT.

Thanks everyone so, so much for your replies. Love ya'll!

Best of luck.

[November Fox]

Hey King Phoenix,

Thanks for this thread, I was dealing with similar questions. I haven´t had any blood clotting history as of yet, but have a greater risk (family wise), and like you I got the impression that I was about to be possibly denied TRT because of it... it´s too bad that these things are never easy, it seems to be a constant struggle between patient and healthcare provider to see who´s got what information right...

I think I´ll be dedicating a post on my blog about this, seems about time the misconceptions about this got set straight. Anyhow...

As I was at risk, I´ve always avoided anticonceptives, but periods are a complete nightmare for me. So far my GP said that there´s no way to stop the periods without increasing my risk for blood clots, so I´m curious to know what they told you about the IUD placement. Could you tell me a little bit about that?

About the comments your endo made... in my opinion when someone asks invasive questions, it is still your right to refuse to answer, if you don´t see how they are relevant for your treatment. Don´t give up private things too easily

[KayXo]

As I was at risk, I´ve always avoided anticonceptives, but periods are a complete nightmare for me. So far my GP said that there´s no way to stop the periods without increasing my risk for blood clots

There is a contraceptive pill that contains bio-identical estradiol. Bio-identical estradiol, at the doses found in these pills, is very unlikely to cause problems, more so if taken sublingually. Please ask your doctor about this. I will PM you the name of the pill.

[Tristyn]

Hey everyone.

Just thought I'd mention that if everything goes right, I should see my hematologist tomorrow, I have my fingers crossed, hoping and praying that he will give my endo the ok for T. My therapist even really wants me to be on T.

He wants to show the resources I have found to the endo he knows very well, but I can't see that endo because he doesn't take my insurance. But if that endo can put in a good word for me and can prove that there is no such risk as blood clots on T whether being predisposed or not, then I should start HRT here very shortly. I am hoping for the best, and preparing for the worst, you guys!

[arice]

Good luck tomorrow!

Sent from my SM-G870W using Tapatalk

[Tristyn]

Thanks, arice.

[stephaniec]

good luck , I know how important it is.

[Tristyn]

Thank you, Stephanie. ^^

[Tristyn]

Lupus (SLE) is an autoimmune disease.

From wikipedia:

"The cause is believed to be an environmental trigger, which results in a misdirected immune response in people who are genetically susceptible."

"Hormonal mechanisms could explain the increased incidence of SLE in females. The onset of SLE could be attributed to the elevated hydroxylation of estrogen and the abnormally decreased levels of androgens in females. In addition, differences in GnRH signalling have also shown to contribute to the onset of SLE. While females are more likely to relapse than males, the intensity of these relapses is the same for both sexes."

"In addition to hormonal mechanisms, specific genetic influences found on the X chromosome may also contribute to the development of SLE. Studies indicate that the X chromosome can determine the levels of sex hormones. A study has shown an association between Klinefelter's syndrome and SLE. XXY males with SLE have an abnormal X-Y translocation resulting the in the partial triplication of the PAR1 gene region."

Klinefelter's syndrome affects genetic males only, however did you have testing done for possible intersex condition ? That certainly should be taken in account for your HRT (and also for the treatment of the lupus, probably).

"The rate of SLE in the United States increased from 1.0 in 1955 to 7.6 in 1974."

Do you know that a lot of autoimmune diseases and more generally modern chronic diseases have been positively associated with the consumption of sugar and refined carbohydrates ?

Hi Lucie.
That's a very interesting bit of information there. Though my professors usually frown upon citations from Wikipedia because anyone, and I mean anyone, can manipulate any of the given information there. I wouldn't take what Wikipedia says with a grain of salt.

But I do want to get tested for a possible intersexed condition. It's funny that it talks about low androgen levels in regards to SLE, because mine's are low. I never heard of Klinefelter's syndrome. I will look that up. Perhaps this may be a connection. Sorry for this noobish question, but what does "translocation" and "triplication" mean? What is the PARA1 gene region? O.o

Oh and I am certain my diet growing up had alot to do with it too....the lupus I mean

[Lucie]

Sorry for this noobish question, but what does "translocation" and "triplication" mean?

Hello King Phœnix,
From wikipedia: "In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes."

As for "triplication", I guess that it applies to the case where two extra copies of a given chromosome segment are present in individual's genome.

What is the PARA1 gene region?

From wikipedia again: "The pseudoautosomal regions, PAR1, PAR2, and PAR3, are homologous sequences of nucleotides on the X and Y chromosomes."
Broadly speaking, PAR regions are parts of X and Y chromosomes which are similar on both chromosomes.

Good luck for starting your HRT.