Hi Randy,
You can get a good idea of the costs by going to a site like goodrx.com. Without insurance, spironolactone (50 mg tabs) is about $10-15/month. Estradiol prices vary greatly, depending on the dosage form. Tablets (1 mg) are cheap - also about $10-15/month. Transdermal patches (0.1 mg/day) are the most expensive - they can run $30-80 a box without insurance.
Hope that helps.
With kindness,
Terri