Some of these side-effects like sweating, hot flushes, mood changes, headache are due to the medication significantly decreasing T without hormone replacement in men. If you take estrogen and enough of it to compensate for the loss of T, you shouldn't experience these side-effects. In general, this medication appears to be *relatively* safe, I personally never read any complications from it in transwomen. Used alone, it actually raises T levels the first couple of weeks, thereafter leading to castrate levels of T.
It's used in pre-op transwomen.
