Hey everybody, just putting this here in case anyone's interested! I came across an anime yesterday in which the main character is ostensibly a young FTM girl and another central character appears to be an MTF boy (they're in middle school). After 5 episodes, I can definitely say I'm enjoying this, and it seems to put a very positive light on the LGBTQ+ community!

It's called
Hourou Musuko Wandering Son and you can watch it for free on CrunchyRoll at:
http://www.crunchyroll.com/hourou-musuko-wandering-son/wandering-son-introduction-568704P.S. I included the "possibly?" in the post's title because while it seems pretty clear that the two aforementioned characters are indeed transgender, without finishing the anime, I can't be entirely certain.