I've always used patches, and I've gotten great results. I did, however, definitely have to switch to the twice weekly - the once a week ones were giving me terrible PMS for the last 2-3 days of each week. (That may have been the manufacturer rather than the nature of a weekly patch; I was using the Mylan generics for Climara, and those have since been tested to show that they deliver more estrogen in the first couple days and then it tapers off. Which defeats the purpose of a patch for the sake of steady delivery! Now I'm using Vivelle [that's Estradot in Britain] and loving it.) I'm actually within the range of doses provided to menopausal cis women, too, so the few times I've had to explain it to a doctor, I just say I'm in surgical menopause relatively young... which is absolutely true, as far as it goes.