I second Jane Emily's experience. I went from moobs to Tanner stage II, enlarged aereolae, nipples everted, hard masses behind, in under two weeks after starting Estrodiol at a low level via patch. My tank tops are getting tight. The pads I had been using to 'stuff' are now too large, and at this rate will be unnecessary in another month. I blame a high prolactin level for priming me, but that's just a guess.
I guess I don't have a problem with patches...