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Started by Orchid, December 26, 2016, 09:53:16 AM

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Orchid

December 26, 2016, 09:53:16 AM
I have a question about testosterone blockers. MtF here, been on hormones for about a year now. I'm alright with staying on the medication that I'm currently taking (spironolatone oral and estradiol valerate intramuscular), but with work I'm never going to be in the same place, and I really hate taking my medication with me while traveling, and staying consistent with my spiro.

I was wondering if there are injectables that do the same thing spiro does, implants, anything like that which I can take less frequently than spiro. I've been to local support groups but I think everyone uses the same medication I use, so maybe I'll get some help here. Any is appreciated.
Thanks all
10-22-15 - Begin
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KayXo

#1
December 26, 2016, 10:08:53 AM
Estrogen will suppress testicular production of testosterone and also spermatogenesis through negative feedback inhibition at the pituitary gland (and hypothalamus) so that, especially when it comes to implants and injections, high levels will sometimes suffice. I know transwomen who take (took) EV intramuscular alone pre-op and were fine, their T levels were very low, on par with castrate levels.
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Orchid

#2
December 26, 2016, 10:13:04 AM
I really don't know what's considered high for injections. I'm on a weekly dose - pretty sure I can say that here - and I think it's higher than the norm, but I can't really tell. It probably is enough, but I'm on the 'standard dose' for spironolactone, have been since I started. I don't really like the results that it produced, personally. I noticed an on and off thing of hair growth, one time it looks good, the other time it doesn't, all while being on consistent doses. That goes for overall changes as well. I've been pretty discouraged by all things in general.

I don't feel too confident in my provider, so I'm going doctor shopping in a bigger city I'll live at the coming year. I switched to injections Mid October of this year.
10-22-15 - Begin
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KayXo

#3
December 26, 2016, 10:14:58 AM
The only way to finding out is through trial and error, gradually decreasing Spiro and seeing what happens. Of course, you need to do this with your doctor and with their consent.
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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rose

#4
January 09, 2017, 01:27:23 AM
Androcur[emoji768] Depot is very strong injections ( cyproterone acetate ) in form of injections but I never found anywhere


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MjaGi

#6
January 10, 2017, 06:41:47 PM
As rose already said, Androcur. Its a very effective blocker, as far as I know a lot more effective than spiro and it also lasts longer. But I heard it would be forbidden in NA because it brings too many risks like liver damage, brain tumors, heavy depression etc. etc.
I've been taking Androcur since the start and can tell you ... it works damn good but ... the part about depressions is true. If you have another choice better stay away from it
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Ellement_of_Freedom

#7
January 11, 2017, 02:40:40 AM
Quote from: MjaGi on January 10, 2017, 06:41:47 PM
As rose already said, Androcur. Its a very effective blocker, as far as I know a lot more effective than spiro and it also lasts longer. But I heard it would be forbidden in NA because it brings too many risks like liver damage, brain tumors, heavy depression etc. etc.
Liver damage and brain tumours? ...


FFS: Dr Noorman van der Dussen, August 2018 (Belgium)
SRS: Dr Suporn, January 2019 (Thailand)
VFS: Dr Thomas, May 2019 (USA)
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KayXo

#8
January 15, 2017, 04:16:05 PM
Androcur has been associated with 9 meningiomas and 5 prolactinomas in transsexual women. The link with meningioma appears to be quite strong.

Liver damage seems more likely with higher doses. Check info with your physician.
I am not a medical doctor, nor a scientist - opinions expressed by me on the subject of HRT are merely based on my own review of some of the scientific literature over the last decade or so, on anecdotal evidence from women in various discussion forums that I have come across, and my personal experience

On HRT since early 2004
Post-op since late 2005
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Lucie

#9
January 16, 2017, 03:49:05 AM
Quote from: KayXo on January 15, 2017, 04:16:05 PM
Androcur has been associated with 9 meningiomas and 5 prolactinomas in transsexual women. The link with meningioma appears to be quite strong.

I've found only one article, not really convincing, about the possible link of prolactinomas with CPA:
Prolactinoma induced by estrogen and cyproterone acetate in a male-to-female transsexual.
Fertil Steril. 2010 Aug;94(3):1097.e13-5
Do you know good references which show causation or at least association between CPA and prolactinomas ?
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AnonyMs

#10
January 16, 2017, 05:24:43 AM
Quote from: Orchid on December 26, 2016, 09:53:16 AM
I was wondering if there are injectables that do the same thing spiro does, implants, anything like that which I can take less frequently than spiro.

This one last 6 months

Lupron Depot (6 Month) intramuscular
http://www.webmd.com/drugs/2/drug-156149/lupron-depot-6-month-intramuscular/details
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