I've done oral, sublingual, rectal, patches and IM injections, now on gel (Estrogel). I really liked the injections a lot, relatively easy to administer but levels would fluctuate quite a lot. Rectal suppositories were also quite convenient but it wasn't absorbing as much as I'd like them to. Oral was easiest but felt awful on it, skin was so dry, I couldn't sleep, I was quite anxious. HOWEVER, it's the one route that gave me the most breast growth, by FAR but I was also on a high dose. Sublingual didn't make a difference relative to oral, for me and it was a pain in the @#$ to take it that way. Patches left red marks, very difficult to remove. No thanks. Right now, I'm on gel and no complaints so far.

I believe levels are quite steady on gel.