My observation is that people of mixed gender, or "non-cis," often have gender hormone clashes that cause depression, among other things.
Anyway, I've fought depression since it dawned on me I don't fit in with societal expectations. I didn't really know how I was different, but I knew I wasn't like my happily integrated siblings and friends.
I began getting panic attacks in my early 40s, so learned to take hormone-balancing herbs, eat fish etc. I also exercise outdoors, have many outdoor hobbies, keep pets, focus on things that make me happy, do a lot of reading, whatever keeps me from mulling over past failings.
None of my relationships lasted, but since I'm bigender/partial transmale, I can see why, since I was trying to play the role of a female.
The main thing is to find what makes you happy and think about and do only that.