Hello,
Based on the estimated percentage of trans people in the US, there is already a likely chance that one of the 45 occasionally slipped on a pair of heels in the Oval.
As for as electing an openly trans person? Gulp, I can't see that happening. From what I have seen, the link between religion and politics has become inextricably entangled in the US. For many, this has become their yardstick in which to measure everyone to their narrow view of morality. The far right espouses freedom but they only seek freedom for those that agree with them. For the MAGA tribe this is white, christian, straight, male, etc. Any trans person that would run for would be subject to a litany of attacks from the pulpits, general population, and right wing media such as FOX. It would take an incredible person to overcome this onslaught of hate and ignorance.