Side effects? Leg cramps were a problem when I was on the patches, largely because my E levels were not high enough. They disappeared when I switched to injections. Sore nipples, yes, but that means my breasts are growing and that is a very happy thing for me. So yes, I try to protect my breasts from over aggressive hugs, bumping into doors, etc.
I also have had problems with cold hands whenever the weather is cold, and an overall greater sensitivity to the cold, probably because my skin has become thinner.
But the side effects are worth it. I am calmer, more patient, a better listener, I have better intuition and a better ability to read people. No more panic attacks. I am a less aggressive driver. I have much less of a temper than I used to. Oh -- and I got boobs, a nice hiney, pretty legs, and my face has been changing so rapidly that my profile pic is outdated even though it has only been up for two or three months.