I was on horsepee for a 8-9 months. It did some things. However, it made my legs always feel achy. I didn't feel too good on it after those many months, so I switched to Estrace and I felt much better and I also started to notice a lot more changes . I've been on Estrace for 7-8 months. It seems to work for me, with no side effects, and I feel better over all. Plus, I swear I changed a lot on Estrace vs horse pee.