As stated, every doctor is different. The body is very complex and noone can say for certain exactly how anyone will react to any single medication. So mine only changes 1 thing at a time and only adds one thing at a time in order to better pinpoint the drug that's causing my issue. It's like trying to nail jello to a wall.
I started on a low dose in order to see how I was reacting to the Estrogen alone, then added in Spiro 3 months later to see how I would tollerate it. Then Finasteride 2 months after that, since I was not having any bad reactions to any of the previously introduced medications. Then they did some blood work and increased my Spiro again. I had issues after the increase in Spiro, so she played with Estrogen dosages to correct that. Then added Medroxyprogesterone. I had issues when it was added, so she played with the Medroxy doses to see if it got any better. And when it didn't, she then played with the Estrogen doses to see if she could get rid of some of the adverse symptoms. Then took me off Medroxy and played with my Estrogen levels to find a different level that she and I were comfortable with, then recently added Micronized Progesterone. All of that is confusing enough when it's only one medication change at a time, change multiple things or having started them all at once, neither one of us would know exactly what is going on.