Yes, I noticed changes. I knew starting around day 3 when I felt like I had cotton balls in my head and I didn't have any of the same intensity in thoughts. My levels of anger and irritation generally reduced consistently. After a few weeks of fuzzy brain, I felt more like my usual self but less dysphoria and more relaxed. Thankfully this has continued. I always hope for more physical changes, I just hope it doesn't stop. I am on a low dose so far and it has been better than anticipated.