Do you happen to take your estrogen SUBLINGUALLY/BUCALLY? Levels will spike the first 1-3 hours if you take your pill this way and then quickly fall.
I've had levels over 1,000, as high as 4,000 pg/ml with injections.
Prolactinoma, a tumor of the pituitary, causes prolactin levels to rise significantly and not estradiol levels to rise. High estradiol levels will trigger prolactin secretion, that is perfectly normal and in that context, the high prolactin levels are due to estrogen, not a tumor. Estrogen has never been shown to be causally linked to the onset of prolactinomas. Despite decades of very high dose estrogen use in transsexual women, there are only 8 prolactinomas reported in the literature. Women become pregnant, with high levels of estradiol (up to 75,000 pg/ml), high levels of prolactin (up to 600 ng/ml) and don't chronically get prolactinomas. Pregnancy is not even contraindicated in women with microprolactinomas and sometimes, the tumor even regresses following pregnancy.
