Does Spironolactone immediately prevent testosterone from masculinizing me?

[andrejce45]

I'm currently using Spironolactone and the dosage are pretty high. I'm just 15 years old and my endo told me that within 1-2 month my testosterone would me in female range so she'll introduce me to estradiol, but now what can I expect from Spironolactone alone to do with my body and testosterone levels?

[Deborah]

By itself it will lower your testosterone production.  This will in effect put you in a pre-puberty state where you are neither masculinizing nor feminizing. 


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[Devlyn]

In medical terms my T stayed in the same range on Spiro. It actually rose a couple of points. Voice your concerns directly to your doctor, it doesn't matter how medicines affect other people.  What it does to YOU is the only important factor.

Hugs, Devlyn

[KayXo]

Studies have shown that even at high doses, spironolactone may not always lower T levels BUT may still produce gynecomasia and other symptoms like reduced libido, erectile dysfunction, etc, the reason being that spironolactone and its metabolites bind androgen receptors and prevent T from doing its job. Relying on levels alone may thus be misleading and just plain wrong.

[AshleyP]

Studies have shown that even at high doses, spironolactone may not always lower T levels BUT may still produce gynecomasia and other symptoms like reduced libido, erectile dysfunction, etc, the reason being that spironolactone and its metabolites bind androgen receptors and prevent T from doing its job. Relying on levels alone may thus be misleading and just plain wrong.

What Kay reports has been exactly my experience while on spiro only. I experienced all the symptoms above on a low dosage over several years. Elevated dosages didn't reduce my T levels. I've come to believe that spiro is a lot better at blocking T absorption than suppressing T production. YMMV

[KayXo]

My doctor confirmed yesterday that I was correct and that on Spiro,, checking T levels is useless and doesn't give the whole picture. Same goes for bicalutamide (obviously) and cyproterone acetate.