The main issue is calcium loss in your bones if you don't take some type of sex hormone. Other than that, there shouldn't be any additional health risk. There is another possible appearance issue without sex hormones. Sex hormones hold body fat in it's proper location and without it, you might appear older. In my case, I lost facial fat ad looked like I lost far to much weigh even though I was over weight. On estrogen, I have regain my facial fat and I weight 30 pounds less.