Quote from: Dani on January 02, 2018, 06:58:16 PMBreast development is not dose dependent.
QuoteThe exact dose is not that important.
I personally disagree. In my 13 yrs on HRT, I have personally witnessed this. Nothing happened on lower doses (of oral estradiol) and finally, on higher doses, it did. If development wasn't dose dependent, then why are we even taking any estrogen at all or why is there a minimum?
J Clin Endocrinol Metab. 2003 Aug;88( 8 ):3467-73."breast growth was enhanced with higher estrogen levels (14)."
Arch Sex Behav. 1981 Aug;10(4):347-56."The higher the dosage of estrogen of either type, the more breast development occurred."
"Since a majority of the patients had no change in dosage, one cannot assume that the greater response in breast growth, testicular size reduction, and hormonal suppression by the higher doses of medication were due to the total length of treatment."
Also,
Horm Metab Res. 1994 Sep;26(9):428-31."Pseudopregnancy had been used in sterile patients with hypoplasia of the uterus and for hypoplasia of the breasts (Kaiser 1959; Lauritzen 1992)."
"pseudopregnancy may be useful and effective in osteopenia and lacking secondary sexual development due to gonadal dysgenesis like in Ullrich-Turner syndrome (after completion of growth), where
substitution doses of ovarian hormones may be not sufficient enough to guarantee satisfactory response."
During pregnancy, levels of estrogen and progesterone significantly increase and as a result of this and other factors, breasts significantly increase and expand.