This is a thought-provoking topic.
I do agree that being trans is a handicap; but I don't like to say it that way. I think it's because I tend to associate the trans label with my womanhood, which I do
not consider a handicap, rather than the disjunct between my gender and my birth sex. I wonder if most of us don't tend to do that -- which, if so, would make the "handicap" label burdensome.
Functionally, though it's a good way of explaining the effects of being raised to present the wrong gender. It is definitely a monkey on the back -- like Carly says, going through life with one hand tied behind you. My experience has been similar to hers; I have always functioned far below my theoretical potential. It's hard to perform with dysphoria.
EDIT: I was journalizing before getting ready for work and had the most amazing realization. Since it's relevant to this topic, I thought I'd share it here. I just need to tell someone.
I've had to continue presenting male since coming out to myself, until this week (yay, full-time, finally

); and I've noticed before that this frustrates the emergence of my feminine self. It perpetuates the male mask I've acquired and lived under all my life. At any rate, I've noticed recently how much I still communicate like a man -- perhaps even think like one -- and it's a bit discouraging.
Tonight, however, it suddenly struck me that the mask is slipping away. Maybe going full-time is what did it, although if so this seems rather sudden. Still, I have the definite sense that it is slipping away
and that the problems I've had all my life are going with it. That was unexpected, and frankly astonishing.
I'm one of those girls who had dysphoria and never knew it. I thought it was low self-esteem. Since coming out, I've been able to see it for what it was; still, it's amazing how powerfully negative an influence over my life it has been. Just think: all those things that have burdened me, just slipping away with the mask.