I was taking spiro, dutasteride, and progesterone, but stopped all of those to experiment, and see how I fair on just estradiol alone. I'm not disappointed as of yet. A slight-moderate increase in sex drive, but other than that... I feel fine. Will be doing blood work in a few days, will post back with the results. This is completely experimental. I want to know for myself personally whether or not all that extra stuff is actually expendable without sacrificing results. I have plenty of it available to me, so availability is not a concern. If I have great blood test results, I might just roll with this, but if things are a bit off, I'll continue back to my regularly scheduled broadcast.