For me, the mental peace has been astounding. I wish I could fully convey the feeling of mental clarity. It took about 2-3 weeks or HRT, but then the fog just started to lift and has been gone ever since. Personally, I'm not sure if it is the lack of testosterone, the addition of estradiol, or the combination, but it was a life-saver for me. While I feel good now, and as so many can attest to, I feel "cured", I know if I go off HRT it will all return and I don't think I could take being like my old self ever again. For me there is a lot of downside to this also as I'll be separating from my wife in the next few weeks, leaving my job, leaving my hometown, and one of my daughters wants nothing to do with me. She doesn't even want me to see my grandson now. Ugh. Couple steps forward and fifty steps back in a lot of ways it seems. Even so, and as much as my family issues suck right now, I still think I've made the right decisions overall for everyone involved. I'm alive and not wishing for death anymore. Here's to keeping my fingers crossed.