Quote from: josie76 on December 12, 2017, 06:30:06 AMprogesterone is the primary precursor route of nearly every regulatory hormone and gene action modifier in the HPA axes and the HPG axes.
I believe cholesterol is the primary precursor of all hormones.
Quotecontrolling cholesterol, triglycerides, and lipids produced.
PLoS One. 2014 Jan 21;9(1)"Progesterone (n = 65) and placebo (n = 47) groups had similar changes in systolic and diastolic blood pressure, resting heart rate, weight, body mass index, waist circumference, total cholesterol, low-density lipoprotein cholesterol and triglyceride levels."
"Results indicate that progesterone has short-term cardiovascular safety. Endothelial function, weight, bloodpressure, waist circumference, inflammation and coagulation were
unchanged"
J Hypertens. 2003 Jun;21(6):1145-9."In a randomized, double-blind, cross-over design study, 20 healthy postmenopausal women were tested before and after 6 weeks of treatment with micronized progesterone"
"Systemic arterial compliance, flow mediated dilation, cutaneous vascular reactivity, blood pressure, body mass index, plasma levels of cholesterol, lipids and oestrogen were
unchanged."
Acta Obstet Gynecol Scand Suppl. 1984;127:1-37."During treatment with natural progesterone, no changes were recorded in HDL cholesterol or its subfractions."
Quotecis males produce their body's needed progesterone from the testes and in much smaller amounts from the hypothalamus in the brain. We trans-women remove the testes production at the same time we lower or remove the testosterone production from the testes.
Logically following is trans-women operate on a progesterone deficiency overall.
Progesterone levels are VERY low in males, so low as to be insignificant, less than 1 ng/ml.
Quotecis females bodies produce progesterone at female levels beginning with the first menstral cycle. So while they grow up having a few years of pre-puberty with mainly slowly rising estrogen, the remainder of their lives, their bodies produce progesterone to match estrogen in ratio. (This ratio drops off as they get towards middle age and menapause, see increased symptoms associated with decrease in P in the ratio).
Logically following trans-women are at a significant progesterone deficiency when comparing ratios of estrogen.
Ciswomen need progesterone for pregnancy, for their fetus to grow. We cannot become pregnant or give birth at the present time...maybe in the near future.
QuoteBreast development, a number of sources indicate stage5 is only reached after several months of pregnancy level estrogen and progesterone and that in early trans women who were treated with synthetic estrogen's that cone shaped breasts were a common situation until progesterone was added.
Biologically in breast tissues, progesterone works with HGH and insulin with like growth factors 1 and 2 to mature the tissues. Progesterone and estrogen work in synergism in breast growth and development. In other words one increases the effectiveness of the other.
And yet, XY women, insensitive to androgen, often develop large mature full round breasts just on low levels of estrogen and insignificant levels of progesterone.
