Estrogen name vs generic

[SailorMars1994]

Hey there. I am curious about the difference between name brand vs generic E pills. Recently I moved to a small town and decided to use the pharmacy in town. I used to go to rexal and Walmart for my hrt. Anyways the town pharmacy has estrogen but it's name brand and not the copy cat version. Imhas anyone expericed going from name to generic? I wonder beciase I was scratching an itch on the boob and felt my nipple having a hard bud feeling. I haven't recalled this feeling at any point since 2015 when I first began which is why I ask. About two days ago and yesterday I noticed slightly more pain in the gentian area similar to when I first began. Not knocking on the generic brands as they did the job of feminization tonthe point I pass but I am curious if any of this is relatable or pure coincidence?

[Maid Marion]

https://www.fda.gov/drugs/resourcesforyou/consumers/buyingusingmedicinesafely/genericdrugs/ucm167991.htm

You could research the manufacturer to see if the company is having any issues recently.  Though this may really be a question about HRT and boob growth.

[Rayna]

Generics are "supposed" to be the same as name brand. They are the same chemical formulation.

That said sometimes there are differences in subtle areas that aren't part of the certification. Chemical "chirality" (left-hand vs right-hand), fillers, solubility, etc.

As Marion said it can just be time...you'd have reached this point with either. But there could be a real difference.

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[SailorMars1994]

Thabks girls! Make no mistake the other estrogen pills I was on were doing their job however I noticed small things recently I hadn't before or in a long arse time so I wanted to find out. Thank you all!

[cluck1992]

I'm not on HRT yet, but name brand food taste a lot better than the generic super market version, I know it's not quite the same but I'm sure there is some truth to it...

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[Colleen_definitely]

I'm leaning a bit more toward coincidence here.  The generic companies aren't using a different method to produce the stuff, they follow the method in the patents.  It's a proven method, doesn't need more FDA (or the Canadian equivalent) approvals, and this means it's cheaper to produce since they don't have to dump money into R&D.  The generic producers are all about cranking out the same stuff at a low price and they get in trouble if they don't produce a clone of the brand name they are copying.

[Dani]

For most generic drugs, they function just as well as name brand drugs, but there are some differences.

The active ingredient is the same. If there is any difference, it is in the other items such as fillers and binders. Fillers are non-active ingredients needed to bulk up the tablet to a manageable size or give a tablet a specific color. Binders hold the ingredients together in a tablet form until the active ingredient is released when the tablet dissolves. Sometimes a person may be allergic to one of the fillers or binders in the generic or brand name drug.

Sometimes the amount of pressure used to compress the loose powder into a tablet is too much. This makes the tablet harder to dissolve and it just takes longer to get into the liquid state before absorption. Sometimes a coating can delay absorption, there by lowering the peak drug level.

Even though the active ingredient is the same, fillers, binders, compression and coatings do affect the more subjective responses any one person might experience.

Does this make any difference? Usually not.