Not really.
I'm a self-centered person. I don't mean that I'm a selfish monster, I mean that my life has always been predicated on self-preservation in order to function, and self-aware of its own level of discomfort. I believe I'm here and alive for myself primarily and don't exist for someone else or for society (I don't have any kids, that would be the only exception for my situation). Maybe that attitude comes from being isolated or feeling isolated. But the whole point of living in my opinion is to come to understand and appreciate yourself so you can understand and appreciate life.
Being trans throws a massive spanner in the works when it comes to understanding and appreciating the lived experience.
I bother doing it because if there's an opportunity to self-actualize better and improve the lived experience on a personal level, it has to be done if it can be done. To not do it when I could do it and never know if I could reach a better plane of existence would be something to answer for when it was too late to act.
Friends? Those can be replaced. There is no use for a friend who behaves like an enemy.
Family? Those can't be replaced, but again, if they behave like an enemy, what good are they? And what real justification do they have for behaving like an enemy over something like this? This is a condition, in my case. I didn't choose it, I didn't ask for it, I don't want it, and it affected my life negatively to the point I sought medical intervention. If they begrudge me that to keep up appearances, they can shove it where the sun don't shine.
Society? What do I owe society that can't be paid after transition as before?
(I guess it's a question of attitude. Mine has always been reactive. Don't mess with me and I won't mess with you, sort of thing. I don't ask for anything and I don't take anything that doesn't belong to me. Therefore I owe nothing to anyone else. Nobody has a right to interfere with my life if my life is not interfering with theirs.
I do think isolation probably has a lot to do with this attitude, but I don't know any better. I've always been isolated and "different").