Thursday, October 4, 2018, ContinuedThe Estradiol/Estrone Dilemma...For my last blood tests, I asked the doctor to order not just the standard estradiol and testosterone levels, but also estrone, estradiol, and total serum estrogen. This was because
@SassyCassie had told me about a doctor in Michigan who had done a lot of research on the transgender condition and was becoming well-known for his effective methods. He'd recommended monitoring all those numbers. I didn't know at the time exactly why I was collecting them, but I knew I could figure it out later once I had the data.
The numbers were, well, weird. My estradiol looked good, 274 pg/ml. But estrone was 1574 pg/ml. The expected numbers for ciswomen are in the luteal phase, 16-173 pg/ml. And total serum estrogen was 2582 pg/ml. The highest expected in ciswomen is 590, during the follicular phase. I didn't know what my numbers meant, and neither did my doctor, but I knew they were way out of whack. Doc theorized that there had been a mistake, and we should let it ride until we had another set of numbers at the next 3 month check, to develop some sort of baseline.
In the meantime, two things were going on. Cassie wasn't satisfied with her numbers either, so started researching estradiol valerate - the intramuscular injectable. It has been in very short supply for at least a year, but after a lot of work, she determined that it was once again available. She got her prescription, and I got curious.
Simultaneously, I had been studying the work of the doctor I mentioned above. Dr. Will Powers had put together a PowerPoint presentation about the Care of the Transgender Patient, and I downloaded and studied it. And he spent five slides talking about exactly the kind of numbers I had. He sees that in 1/4 to 1/3 of his patients. The problem? With estrone that high, the estrogen receptors in the body are flooded with estrone instead of estradiol. And estrone is only 4% as efficacious as estradiol. So even with the good estradiol numbers I'm showing, I'm getting only 4% of the benefits. He found that those patients were among those swallowing the estradiol. When he switched them to valerate or topical application, the numbers straightened themselves out, and the increased rate and effectiveness of feminization was readily apparent. In the the nearly 16 months I'd been on HRT, I'd seen some body improvements, but I attributed what few changes I could see in my face to better skin care - and of course breast growth is never enough, is it? I copied the presentation onto a flash drive and made an appointment with my doctor for Thursday.
I do want to point out that though Dr. Powers found a certain number of his patients have this problem, 2/3 to 3/4 of his patients are doing fine on oral estradiol. So YMMV and you need to get properly tested and work with a doctor on this stuff.My doctor is very open-minded and ready to listen, and he's come to trust my judgement and research on these things. We have a good working relationship, but he's also cautious and wants to take good care of his patients. My expectation for the day was that we'd have a good discussion and he'd agree to study the presentation, and follow up with another consultation before any decisions were made.
Instead, I walked out with a prescription for estradiol valerate. Or should I say, I
floated out! The day before I had checked if my local pharmacy could get it, and while it wasn't in stock, it was readily available for ordering. While needles and I have a very uncomfortable relationship, I can't wait to try it. If I can't stick myself, there are a few people around who would be thrilled to stab me!
More to come!Stephanie