Quote from: Keira on February 07, 2008, 05:25:11 PM
But, I countered that there wasn't any proof of birth order and being TS but there was seemingly a correlation between the sex ratio in ancestors in the female line and being a TS.
So, the initial question itself makes no sense if there is not TS to birth order link.
Schala, I didn't ignore partial insensitiivity. Its just much clearer to talk
of cases where the differences are very clear.
Also, are you sure about partial AIS and TS 5-10% are TS, is this even measurable since even the male population, sensitivity to androgens
and tissue response to stimulus vary immensely. I suppose that they can establish an arbitrary threshold when it has some physiological impact (say smaller frame, less muscle mass, effects on the gonads, etc)
But that would be an ad-hoc diagnostic a good measure since there is a difference between the sensitiivty of the receptors and how the cell reacts to this. You could have a low sensitivity yet a high expressivity (gene expression). Meaning a low stimulus creates a big reaction (this also based in our genetic makeup but not related to sensitivity). Also, the response could be different from tissue to tissue. In those with total insensitivity, the different tissue response doesn't matter and its clear cut.
I'm speaking of those diagnosed. I can't speak for the undiagnosed, although I might be one. Typically, if you produce normal levels of testosterone, and have normal levels of LH and FSH, and abnormal development, the possibility is greater.
I mean, typical testosterone range would normally result in a typical physical development when compared with your extended family of same chromosome make-up (like body hair, facial hair, breast growth, pubic hair, armpit hair, baldness).
If it doesn't, then something might be worth looking at.
Complete AIS is typically diagnosed in-utero (pre-screened because of previous family incidence) or at puberty (absence of menarch), though sometimes also in adulthood, it depends on parents involvment and knowledge about the child's health. The diagnosis rate is pretty high.
Partial AIS is typically diagnosed either at the same time as its Complete form (pre-birth or puberty), or at birth if there is ambiguity, or in childhood. It results more often in ambiguity.
Mild AIS is either diagnosed at birth pre-natally, or by fluke by a doctor who thought something was amiss for a phenotypic male (and apparently, it takes a lot for them to think something is amiss).
Typical 'clear' indication of MAIS - gynecomastia to a significant degree, post puberty, or larger during it. Infertility (usually because of trying to conceive, so later in life). Hypogonadism (probably younger, but not necessarily).