For me I have little respect for my family. I do not buy, they are my family no matter what. They were by far the least understanding and most cruel. But I had a pretty negative history to begin with. We cut each other off, I saw them as worthless subhuman bigots and told them so. Family is pretty useless when it gets down to it. To say family is family, would mean to take harmful and abusive language, and bigotry. When it gets down to it blood is pretty meaningless if they do not respect your decisions. Family is like any other relationship, if they do not demonstrate tolerance, understanding, and support, they do not deserve to be talked to and should be cut off immediately. They are no different then friends, if anything they have a much shorter leash. One chooses friends, no choice is involved with family. You can be stuck with people who in many cases are diametric opposites in every respect. My family for example is conservative, idiotic and bigoted. Where I am liberal, only intolerant of those who are intolerant on the basis of race, gender, gender identity, and sexual orientation, and considerably more intelligent then every one of my family members. They are not worth talking to, and them being family matters very little to me.
Friends. Its not so much I lost them, but I grew apart from men in my life. But this was the effect of me moving to transition. The women I still talk to. Suddenly I became another girlfriend.
Work...well I am still working at the workplace I transitioned at. I have some great co-workers. I mean I may leave one day, but it will be reasons outside of transition.
I think over time, all things do fade. But I think that is less an effect of transition and more of an effect of life. To me. I lost my family.
Friends change. One gets new jobs.
One does not have to abandon everything to fully transition, but when one fully transition everything does change, and some things in life just fade or morph into something else.
With regards to pronouns, I never hear sir from those I know.
Additionally with regards to friends and how supportive they are. Most of my friends were third wave (inclusive) feminists, open minded lesbians, female musicians and bi women. Basically speaking the type of people who respect trans womens female identities and get it.
If you are losing friends as a result of transition, it does speak quite a bit about how you chose friends before hand. Those of us who did not run toward masculinity and were more inbetween with regards to our gender and were in largely younger queer circles have fewer problems. Note this is not always meaning gay, gay men can be very transphobic, the straight identified transwomen who were in the gay community at one point have very different perspectives of the queer community as those who transitioned from genderqueer or androgyne, and were sometimes closer to alternative queer culture where people identify as queer rather then gay. This is kind of complex to explain even to people who spent their time in segments of the queer community, the gay male community is only representing one segment of the larger queer community, and there are divisions within the community. Thats why there are women like me who never quite leave the queer community and the constructs of our circle of friends seem to change very little. With me my friends went from being queer women before to queer women afterwards.