Oh, it's real, alright. I've noticed it myself when I was using the patches. It would be like, every week, the night before, and the night after, I changed the patches, Climara, (7 day patch), I'd have wonderful feelings of euphoria. I'd have other times during the week that I'd feel unusually good. Unfortunately, the doctor switched me to pills, which I don't especially like as much as the patches. I'll ask to change, either back to patches, or injections, when I see him again in a few weeks.