http://en.wikipedia.org/wiki/Kashimashi:_Girl_Meets_GirlIf you never heard about it, it's basically a romance story about a effeminate boy that gets hit by a alien spaceship (hang in there), and the alien brings him back to life, but accidentally switches the gender. Then that boy/girl (who isn't really bothered by the change) goes on a struggle between his/her crush and his/her best friend. It's such a beautiful fantasy land... like a dream...
To be honest I've never liked anime up until here. I've been watching it and I love it in everyway... mostly because my life sounds just like it. I'm just like the main character (at least before her change), and both her and I have a tomboyish best friend that tends to get violent :p. I have a cousin that both looks like and acts like one of the older characters... although I haven't found someone like the last main character, but no one is shy around here.