Well, A: a lack of balls does not make you a woman or a lez, or else the entire Bush administration would be considered butch dykes.
B: I go out on a regular basis drinking with a guy who did fifteen years for murder one. He beat a guy to death in the parking lot of a bar some 18 years ago. You can bet I try (and anyone who knows me knows I have to really try) not to piss him off. Just in case.
So, what do you say when the guy next to you says, "I cut off me balls with a knife." Other than "So, how's that working out for you?"