Saline Injections- 1-16 times a day dosing but some like it because you can stop quickly and it isn't esterfied. Not many people use this outside of the research lab but I know a few who do. I don't have a clue why.
Ester Injections- every 3.5 days to 3 months depending on drug. Less dosing with more instability. The ester process and addition of oil is being debated as to safety but the short answer is there is a difference between them and their effects. Canada is more likely to use cypionate and US is cypionate and ethanate and EU is Nebio, cypionate and ethanate. There are more options when you compound it.
Gels/ Creames- 1-2 times a day topical not on genitals. Higher levels of DHT which is good for us. Attempts to mimic typical daily fluctuation but ignores the fact that T amounts change in the blood in relation to situations, time of day and it isn't a single up and down cycle. Many guys report that they don't have enough effects. More expensive then shots and less then patches. Some react to the gel prep. Dangerous if you are caring for children or pregnant women, can transfer to your partner with skin to skin contact. You can't breathe through the alcohol fumes and have to keep your head back to avoid breathing in the fumes. I have been told it isn't dangerous but I wouldn't want to do it long term. If you aren't prompt at giving this every day at the same time you will find it difficult to handle the swings. This is worse if you are post hysto. I tried it and went back to the injections as they are more forgiving of a late dose and I kept getting dizzy and falling trying to keep my head back. Lots of guys like it because no needles, easy to administer, may mimic more normal levels, less irritation and the ability to quickly stop treatment in an emergency. Dispose of packages properly.
Patches- 2-4 patches a day- Most expensive, mostly ineffective, trouble staying on, reactions to the adhesive and chemicals are more common, multiple patches required per day, need new patches after swimming or getting wet, this stretches the limit of this technology and was never meant to provide the large dose required for HRT. Same issues with the gels and not as many benefits. The only benefit this has is transference isn't a concern but proper disposal is and is harder then the gel. There is still T in high doses in the patch when it is finished and could hurt the environment or animals.
Buccal Mucus Membrane- This is a new technology that I haven't used. Problems include mouth sores, unstable levels, ancidental swallowing, proper placements and retention. If it falls off you have to use a new one, I think. This is another one that hasn't been around enough to know if it is safe but I have no indication it isn't. More expensive and difficult to obtain. I don't know if it can be used for starting transition or if it provides enough in one patch. Basically you wet it and stick on your gums between your cheek.
Pellets- 2-3 times a year- Now this one is my favorite and the method I am currently on. 100% bioavailability, no additives, longer swings, can be implanted by needle or scalpel/ trocar, no remembering, more stability, easier on liver, costs and behaves like testicles. Drawbacks are it is minor surgery under local, surgery needed to stop treatments, possible infections, rejection, scars and hematomas. This is only a long term treatment and isn't suitable to start treatment with but after a year with a stated intent to continue treatment it is reasonable to ask your doctor for it. Canadians please contact me for how to get it in Canada, everyone else can get it in their country.
Oral- dangerous- don't use *oregnon has claimed to be replacing their pellet production with oral methods, they have approval but I wouldn't use it without many years with no side effects because the damage caused is cumulative and zdone longer term.
->-bleeped-<-boy