Time of day one takes medication

[mclova84]

Hello everyone!

I hope you all are enjoying your summer thus far!

I am making this post because I read in another post about how people take vitamins and certain medicines that have massive amounts of this or that in it and at the end of the day it doesn't matter because the body can only absorb so much. It got me thinking....does it matter what order during the day you take your medication?

I started on oral estrogen - 3 times a day and I took them throughout the day and took my Avodart about 9 PM in the evening.  After 5 months I switched to injectable estrogen every 2 weeks.  So now I take a fish oil pill about 11AM....A multivitamin at lunch (around 1PM)....A baby aspirin around 3PM....Biotin around 6PM...and I still take my Avodart at 9PM.  Now this may sound like alot but my doctor assured me all of these were FINE to take.

SO my question is: by the time I take my Avodart, has my system absorbed so many different things that it is less effective? Should I take Avodart first in the morning? Avodart say you should take it AT THE SAME TIME everyday, so I guess I could just refresh and start taking it in the AM, or is it just as effective at the end of the day, after I have taken my vitamins. Of course of all of those pills I take, Avodart is the MOST important to me in my regimen so I want it to be AS affective as possible.

I am not a doctor or well versed in drugs and medications, but I know ALOT of you ladies are so I would love your opinions & feedback.....

[Elwood]

I really don't know. I do believe the TIME when you take your medication matters. I am on Effexor (an antidepressant that helps with my anxiety) and I have to take one with breakfast and one with dinner. If I took them both at the same time, they would not be as effective.

Depending on the medications, you'll want to have gaps between dosages. Some of them you'll want to take with food, some of them you'll want to take on an empty stomach. If you're on a lot of medications, I'd discuss this with a doctor.

I take all supplements and vitamins with breakfast in the morning. I personally think that's the best time to take them.
It is okay to take supplements throughout the day; it causes no harm. I'm really not sure why you'd want to take aspirin everyday... if it isn't necessary, I wouldn't recommend it, and instead suggest you drink more water to help with aches/headaches.

You could try switching the Avodart. I personally would ask my doctor. Tell him or her what you told us. They should have some good afvice for you.

[Keira]

Avodart is a very long acting drug, not sure if it makes a diff or not since
its effect on the enzymes that convert T to DHT is progressive. It
takes a while to build to 95% DHT inhibition as you use it (tough it does
it faster than proscar (finesteride). IF you stop, it takes quite awhile for
the enzymes to recover and DHT levels to go up again.

So, variation in dose can't have much of an impact on DHT unless
its sustained for quite awhile.

Also, Avodart's
effect is not proportional to the dose, 1/10 of a dose is maybe
1/2 to 1/3 as effective as a full dose, so even if you get slight variations in
absorbtion, it won't have much effect on

[mclova84]

Ok interesting. Thanks for the feedback thus far.  I just wasn't sure by the end of the day with food and two or three other pills taken, if Avodart would be less effective because the body had already absorbed so much.  I just spoke to a friend of mine who is trans and studying medicine and she told me she felt it shouldn't have any affect, that vitamins tend to be absorbed quickly through the digestive walls and as long as I wasn't taking all of those pills at one time and staggering them it shouldn't matter. She also said what you said Keira, which was that Avodart has a long lasting affect.

Elwood: The reason I take one 81mg baby Aspirin a day is not for headaches, but it is recommended by many physicians to be taken by elder people and those at risk of blood clots. Taking the level of estrogen that transgendered females take, we are at a higher risk for blood clots, so it's a preventitive theory and pretty common.

[Keira]

The clotting caused by estrogen is not helped by taking aspirin,
though there's nothing wrong with using it to stop the other type of
clotting.

[mclova84]

How is the clotting from estrogens different from any other clot? According to 4 different physicians I spoke to, (2 of them being endocrinologists), all who have been medicine for 20 - 30 years, recommended when taking high levels of estrogen to pair it with one baby aspirin a day...why would they all recommend that if it wasn't the case?

[Keira]

Because most endo's, I'd say all endo's never prescribe high levels of estrogens and
don't understand its effects and you said it yourself, 20-30 years in the business,
there wasn't any HRT prescribed and little study on its effects 20 years ago!
Doctors who just came out of school (or internship) would have a much more modern
view and knowledge of this. Most doctors don't fully keep up to date
as much as they should.

Clotting caused by estrogen comes from byproduct of its
elimination from the blood in the liver that flows in the blood
and promotes clotting. Its not that progressive,
it can caused clotting and blockage pretty quickly.


The other type of clotting is a byproduct of atherosclerosis, deposits in the arteries
very slowly block the arteries and sometimes they detach themselves blocking smaller
arteries that feed the brain (strokes), or another tissues (heart or another muscles) causing
partial or total tissue death.

Aspirin helps with the second type of clotting, not the first.

Though, if you've already have partially blocked veins and arteries of the
second type, then you would be more highly susceptible to blockage of
the first type.

[Jordan]

I am extremly interested in this kiera.

Clotting caused by estrogen comes from byproduct of its
elimination from the blood in the liver that flows in the blood
and promotes clotting. Its not that progressive,
it can caused clotting and blockage pretty quickly.

You caused me to find this...

http://health.usnews.com/usnews/health/healthday/071226/aspirin-hormone-therapy-combo-can-shorten-lives-of-prostate-cancer-patients.htm

Good thing Im to cheap to buy sprin, ahha Ive just been taking the Spiro and Estro...