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Microflora of the penile skin-lined neovagina of transsexual women.

Started by Natasha, May 20, 2009, 03:54:47 PM

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Natasha

Microflora of the penile skin-lined neovagina of transsexual women.

http://7thspace.com/headlines/309701/microflora_of_the_penile_skin_lined_neovagina_of_transsexual_women.html
5/19/09

The microflora of the penile skin-lined neovagina in male-to-female transsexuals is a recently created microbial niche which thus far has been characterized only to a very limited extent. Yet the knowledge of this microflora can be considered as essential to the follow-up of transsexual women.
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Feever

Great.

But, what does all that mean? 

How similar is what was found to that which is found in a "normal" woman?

Are the species of flora found good or bad?

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Feever

Ok.  That does answer my question in a way.

Still, I am curious about if the flora is similar to a natal womans.  From what you say, I would think it is.
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Syne

It appears to be saying that post operative male to female transsexuals run the same likelihood of BV as natal women and that the numbers did not change depending on dilation schedules.

CDC on BV
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NicholeW.

Quote from: Feever on May 20, 2009, 08:40:21 PM

Still, I am curious about if the flora is similar to a natal womans.  From what you say, I would think it is.

Do a copy and paste on the names of the microbiota and read about them after you search for them.
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Cyndigurl45

Sounds like a good ole fashioned vinegar doúché would help fix that issue. 
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bahatim

My take after reading this article several times, is that the microflora are different than natal women.  The microflora or the penile skin lined vagina is similar to the microflora of a prepubescent girl, and lacks the receptors for lactobacillus (which are upregulated by estrogen). Lactobacillus actually makes hydrogen peroxide, and LOWERS the pH of the vagina. 

They found that the neovaginas of the subjects had higher pH's (more basic, not acidic).  They also had microflora that was similar to bacterial vaginosis.  Lactobacillus would keep these at bay by lowering the pH.  They assert that the neovagina does not promote the growth of Lactobacilli, whereas the natal vagina does.

This all makes me wonder if we should heed the same warnings against douching as natal women.  Natal women don't want to get rid of the lactobacilli by douching, but if our vaginas are not promoting growth of these healthy bacteria, shouldn't we be doing things to lower the pH?

I leave for Thailand to have SRS in 10 days, and I'm glad to have read this article, but I wish there was more of an impetus to study larger numbers of transsexuals. I read another article that examined the histology of the neovagina (penile inversion), but it also had a small number of subjects.  I just wonder how many conclusions can be drawn from a small number of observations.

I've been reading about yogurt douches and am very intrigued.  Women who do them usually swear by them.
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Nero

Quoteyogurt douches
what does that entail? that sounds oddly refreshing.
Nero was the Forum Admin here at Susan's Place for several years up to the time of his death.
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bahatim

I found the excerpt and link below to be informative, although it remains to be seen whether or not I will implement these home remedies once I'm healed.  I'm definitely all for natural remedies over medication.

http://www.rawfoodtalk.com/showthread.php?t=34762

Easy At-Home Methods to Rebalance the Vaginal Ph

Many women use non-medical methods for treating yeast, because the cost of over-the-counter methods is high, because they are unimpressed with OTC methods, or simply because they prefer more natural methods. Following is a partial list of at-home methods that may be helpful.

    * Insert unpasteurized, plain yogurt with a small spoon or spatula or vaginal cream applicator. Insert at night and wear a pad. Repeat for three to seven nights, until symptoms disappear. Douching with yogurt and water can help, too. It also helps to eat a lot of yogurt.
          o Katie recommends: Another option is to create a douche with water and yogurt and insert it via a squeeze bottle. Straight yogurt is painful for her.
    * "Paint" the vagina, cervix (you'll need a speculum) and vulva (outside area including the labia or "lips" of vagina) with gentian violet. It stains so you'll want to wear a pad. This usually works after one treatment.
    * Insert a garlic suppository. Carefully peel one clove of garlic. Wrap in gauze and insert into the vagina. Leave in for up to twelve hours. Repeat as necessary. It also helps to eat a lot of garlic.
    * Drink cranberry juice. Unsweetened is best.
    * Insert Potassium Sorbate. This is used in home beer-making and can be found at wine-making stores. Dip a cotton tampon into a 3% solution (15 grams of Potassium Sorbate in one pint of water) and insert into the vagina at night. Remove in the morning.
    * Drink or eat Acidophilus. It's available in powder or capsules in health food stores or found in some milk and yogurt products. (Read the label; some dairy products have added acidophilus.)

Post Merge: June 06, 2009, 09:47:14 PM

Reuters Health Stories

Clinical
Microflora of neovagina in transsexual women lacking in Lactobacilli

by Martha Kerr

Last Updated: 2009-06-05 16:32:15 -0400 (Reuters Health)

NEW YORK (Reuters Health) - Belgian investigators report in the current online issue of BioMed Central (BMC)'s Microbiology that the neovagina of male-to-female transsexuals, constructed from penile skin, is largely populated by "a mixed microflora of aerobe and anaerobe species usually found either on the skin, in the intestinal microflora or in a bacterial vaginosis microflora."

In 50 transsexual women with neovaginas constructed from inverted penile skin flaps, the investigators analyzed the vaginal microflora and attempted to correlate its composition with various patient characteristics, such as sexual orientation, the incidence of vaginal irritation, and malodorous vaginal discharge.

"Based on Gram stain the majority of smears revealed a mixed microflora that had some similarity with bacterial vaginosis microflora and that contained various amounts of cocci, polymorphous Gram-negative and Gram-positive rods...sometimes even with spirochetes. Candida cells were not seen in any of the smears," Dr. Steven Weyers and colleagues at the University of Ghent report.

The most common species were Staphylococcus epidermidis, Streptococcus anginosus subspecies and Enterococcus faecalis.

When cultured isolates from 30 of the women were analyzed by tDNA-PCR and 16S rRNA gene sequencing, lactobacilli were found in only one woman. For all 50 women, the mean neovaginal pH was 5.8, compared to the typical pH range of 3.8-4.5 in a natural vagina, which the Belgian team notes is the result "primarily from lactic acid production by the resident lactobacilli."

The microflora in the neovagina is similar to that of premenarchal girls and lacks Lactobacillus organisms typical of healthy adult biologic women, the investigators say.

"A lot of vital cellular material is accumulating in this skin-lined neovagina due to the absence of a natural vaginal 'flow,' which in fact cleans the biological vagina," Dr. Weyers commented in an interview with Reuters Health.

"This neovagina cannot be compared to a biological vagina... It will always stay a skin-lined vagina which harbors a mix of various bacteria. Therefore it should be treated as skin. Local hygiene is probably the most important factor contributing to complaints of irritation and discharge... Further study is necessary to find out ways to overcome this problem."

BMC Microbiol 2009.
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