I have posted this before. Transdermal estrogen DOES have a stronger impact in the area in which is applied. For example, this is why women with vaginal atrophy apply estrogen inside the vagina. Transdermal estrogen applied to the breasts WILL have a greater impact on breast growth, IN THE SHORT TERM. Ultimately, breast size is determined by genetics, if estrogen is present at sufficient levels, over the long term. Thus, you will get faster breast growth, but ultimately not bigger breasts; if estrogen is applied topically. However, there is increased risk of abnormal growth and breast cancer. So, if you apply transdermal estrogen to the breasts, you are risking lopsidedness, oddly shaped breasts, lumps and cancer for somewhat faster development but not ultimately larger breasts.