I have severe osteoporosis, spinal stenosis and a fractured/unresolvable fractured pubis with arthritis in the right shoulder and left hip, sciatica in both legs/buttocks/feet and I can absolutely say that E has not caused me any more or any less pain or discomfort.
What I DO have is a nasty case of passing blood and clots in my urine, but that's prolly from cystitus or so say the VA doctors. It's kinda scary though!!!!
I had to stop E for my chemo (not for cancer, but my osteoporosis) and in a couple of weeks I can go back on it again. I've been off for three whole months now and I miss it badly.
My breasts have lost a lot of their feelings and I feel a little bloated too. No weight gain, but things shift every time I have to take this sabbatical for the chemo. Next year I only need to stop for 6 weeks, they say.
One nice part is that I get a great big spurt of breast growth every time I stop for a couple of months and then start again. Looking forward to that big time!
I've been a full "C" for a couple of years, but the lower areas have filled in a lot and the nipples are perky and up-pointing now.
Ah, well. I hijacked this thread big time - huh!?!
Back to the OP - E didn't have any positive or negative effects on my joints or bones that I can tell.
But - wow - did it help my BPH and I now have the prostate of a 12 y/o.