I did the sublingual thing for about 9 months then switched to Delestrogen IM once a week. There's a bit of a mini-pms on the last day usually where suddenly I find myself hating everyone and everything, followed by a feeling of exhaustion and submission to my fate ,and occasionally hot flashes. LOL. Fun. But it's still better than having to remember that pill...also spiro of course, would like to start progesterone soon. One nice thing about the pill though, it had an anti-depressant effect for me that I only get the first 4 days or so with IM.