Okay, so let's try a different approach.
Quotemy best male friend
Quotehe ordered them on line
Quotewill it be reversible if he chooses
Quotehe has no idea i even know this
Quotewouldnt talk to me if he knew
I can't speak for your friend, but most of us do this because we are girls, women, female. Wer'e stuck in nasty, stinky, hairy, and deformed bodies and will do
whatever it takes to get out. When you look at your friend try to see a girl. Talk to her and treat her like you would a woman. Don't slap her back and say "ok man" or use the expression "d00d". Talk about her in the feminine, and never mess up. I wouldn't want to talk to you either, from what I see here, but it's clear from your other posts that you do care.
This is a lonely row to hoe alone, so if you love this person then be there for her because she's going to need you. The potential and prolly minimal side effects of those drugs are nothing compared to what she's going to go through emotionally. I'll warn you again about the pronoun thing though, we take "him, he, man, d00d" very seriously...it's extremely hurtful.