First, to clarify:
Yes, I donated blood. Within the last month. And I specifically asked them about all my concerns. So I know the regulations.
On the issue of HRT:
Dutasteride and finasteride are on the FDA's list of drugs that prevent you from donating blood. Estradiol and spironolactone are not. The only drug I'm taking that they had any issue with was aspirin. I think the idea is that if you have been taking pain killers, there might be some medical condition you don't know about, but I'm not sure. They were fine with the explanation that I take a low dose daily to help mitigate the slightly increased risk of blood clots due to liver processing of oral estradiol.
The center specifically called me to make sure that they addressed the comment I left them about using the correct pronouns and name, since the process is very gendered, and therefore more uncomfortable for me. So I can only assume that they really do want me to donate blood. They mentioned that there was another trans woman who donates there; she donated there before her transition as well. I specifically asked about piercings in that call, and they said I would have to wait a year to donate again, unless I did it at a doctor's office. No exceptions. And I won't lie about it.
On the issue of the reasonability of regulations:
Certainly there are some overreactions. The BSE issue is one, and so is the lifetime ban for men who have had sex with men. Supposing I have SRS and then have sex with a man ... who the hell knows how that would play. But that's not going to happen, since I'm just not into guys, so it's a moot point. It's stupid, and they need to get rid of that regulation. HIV is a huge problem, but there has to be a better way to deal with it.
The thing about tests is that, for instance, with HIV, you can be positive but test negative for many months after you contract the virus. This is true for a number of other diseases as well. That's why the regulations for tattoos and piercings (a one year ban) make sense. So I'm not going to donate if I get a piercing anywhere but a doctor's office.
So back to my original question:
I guess I'll just try to figure it out and I'll report back once I do that.