advice....while transitioning and still getting used to things, keep your current job. If you have not gotten a name change, started hormones and let them have a good long while to work, feel awkward in social circles presenting as a woman, etc...don't quit and hope to find one that will accept someone openly trans.
I told certain people at my work...namely, my boss and managers. Everyone else I didn't. They'll figure it out sooner or later and meh, my boss' job to keep the peace and keep people working, and me telling everyone would just disrupt and shine a spotlight on me. Of course, YMMV, you might have an office job that a mass-mailing or whatnot is preferable. Either way, transitioning on the job could also give you experience you need as well as present you in a "worse case scenario" deal...there's no guarantee even if you changed jobs that everyone will see you as bio female, even after years of surgeries and hormones, so it would be a good thing to see if you even have the skin to take someone who knows of your trans status.
After I get my documents changed, have top surgery and have been on T for a good long while (at least long enough to where the big changes won't happen as quickly or noticeably) I will keep my current job and search for one under my new name. No one at my new work needs to know I am trans, unless the hiring person inquired why my past jobs were under <femalename> (unlikely as well as I'm going to finish college under my new name and my current work has no relevance to my sought after field).
So in a way, I'm going to do both. I am transitioning on the job, then when the time and opportunity is right, I'll find something that is better suited for me. Also, I would never, EVER put two weeks in (especially in this economy) unless I had some other offer in hand or the job was a threat to my health.
