It seems it's all about testosterone, either the absence of it or the existence of it. And it seems the brain needs to be as equally influenced by it as the body.
I'm not an expert so just ignore my conclusions if you need.
What may be most positive for many is
"There is no indication that social environment after birth has an effect on gender identity or sexual orientation."
Hmmmmm... So an absentee father or a sister who encouraged you to play with dolls, was not the cause of your gender dysphoria? Maybe it was the room your parents painted pink or blue. Yeah, that's it.