I'm with you Jessie,i have been on this earth for a long time and you never can say never happen,about the time you do something will pop up show you different!!! I have been on injecting depo with oral progesterone for a little over 3 years and was on oral estrogen before that and the changes really started coming once i went on the shots and are still ongoing,GYN said for at least another 2-3 years. Most of the ladies i know say i have a better swish than they do and that came naturally about a year ago!!!