Actually, milk thistle seems relatively benign. I took it for years, but recent studies show that it probably doesn't help my particular liver problem. I would be careful of the products that contain mixes with other herbs. I always took a brand produced in Germany under the really strict German laws where it is pharmaceutical quality. Interesting, I just did a search and it has an estrogen like effect also and can cause menstruation. If I start to do that, it truly will be a miracle. Note; I still take SAM-E, S adeno methionene?, for my liver and mental health. Again, very benign profile, while extensive studies under clinical conditions show benefits. It is a drug - read directions. Also, if like me, you are worried about liver fibrosis, drink COFFEE! There is a very high correlation of coffee drinkers with liver disease and non-progression of fibrosis compared with those who do not drink it. If you have a liver disease, best of luck.