The first month was the worst as far as extra bathroom trips went. After about 5 months everything has almost settled back to normal for me. Keep drinking lots of water though. The other thing is depending on your dosage, muscle spasms will increase as well, especially in the legs. Potassium rich foods like OJ, potatoes, raisins, bananas, etc need to be eaten in moderation, but not totally avoided as some potassium is needed in your diet. Your endo should monitor your potassium level as one of your regular reoccurring blood tests.