estrogen receptors

[angiejuly]

 Dig this. Two years off hormones ( thought I could pull off being a straight guy again) and back on for two months now.  I think my body has been making all the reseptors it can since I have been off . When I gave it that first small dosage estridiol in Jan it shot through me. I felt it everywhere relieving everything. My body said ,"there it is". I thought it was nothing more than my own personal excitement. No it really was physical. because I am seeing more soft tissue changes in this first two months than I saw the two years I was on hormones before. lips puffing, and other facial changes that never came the first time. My only physical changes was breasts the first time. I just got back from taking the girls surfing and everyone was saying how good, differant, I look ect. And;" what have you been doing you look so differant. I just looked in the mirror when I got home and all kinds of puffy feminin facial changes are noticable. this never happend last time. too bad I had my breasts removed. I have to go surgery for breasts now.
(If you are trans go ahead and stop hormones if you must but I highly advise not removing any parts that match your inner identity. Whats done is done and I will live)
is it possible I have so many receptors that changes can happen like faster than before?

[Jennie]

That is a good question, it almost makes me want to stop HRT and then start again to see if is kick starts the development but I have to start HRT before I can stop it

Jennie

[pebbles]

I have wondered this... I mean it's a known fact that high exposure to any hormone can cause temporary insensitivity and resistance against it.

See Type II diabetes which is this exact phenomenon caused by insulin rather than estrogen. It's also this effect that causes all the irreversible testicular damage and atrophy in steroid using bodybuilders. (Down regulation of androgen results in apoptosis of testicular tissues once supply is reduced)

I personally was curious to try it by not taking my estrogen for a month or so to see if I could encourage further changes and elevated estrogen sensitivity by arresting my HRT estrogen cycle then restarting it a month later (still taking hormone blockers tho)

My experiment failed however because I became monstrously depressed to the point of impaired function with self-destructive thoughts ect after a week and a half and I had to restart it my depression abated within 2 days or so of restarting estrogen.

It was not a fun experience and I very nearly self harmed again for the first time in 2 years and while I still would like to know the answer of the question and figure this out I have to remember it's not only my physical health that I'm playing with when I "experiment" on myself. I have to worry about my brain as much as my bones. :/

[Jennie]

  My experiment failed however because I became monstrously depressed to the point of impaired function with self-destructive thoughts ect after a week and a half and I had to restart it my depression abated within 2 days or so of restarting estrogen.

It was not a fun experience and I very nearly self harmed again for the first time in 2 years and while I still would like to know the answer of the question and figure this out I have to remember it's not only my physical health that I'm playing with when I "experiment" on myself. I have to worry about my brain as much as my bones. :/

Wow Pebbles, thanks for posting this, i am glad you got through that okay, now I will stick to the direction the DR. gives when he gives them.  I hope I get my letter soon   Aloha.

Jennie

[Colleen Ireland]

Hormones is not something to mess with and do experiments.  This is serious stuff.  A doctor's care is essential.  I know a lot will have a different viewpoint, but Pebbles' experience tells the tale.  Mess with this stuff on your own at your peril.  This is NOT the place to "wing it"...

[justmeinoz]

Interesting question for someone's research paper, but I have waited for so long I will not cease once I do start, unless it is for a really serious medical reason.

[angiejuly]

I highly advise nobody experiment with this. It was hell and very anxious and depressing. I only did not kill myself because I stayed around my girls to not do it. It was really hell and I never want anyone to go through it. I did find out that way that I truly am woman and must transition to live through it. ( should be determind before transition)  I say use therapy instead. However physical changes are happening to me in the first 2 months back on that never even happened the whole time before. I had no facial changes in two years. I already have smaller looking jaw, very puffy lips, softer skin, and body hair is growing very slow like takes 3 to 4  days to see what I saw after one day of shaving.

It`s still not a good thing though. I know I would have even further changes than that by now if I never detransitioned. So I`m still behind. The past is done and I look forward with hope and know there will be obsticals all along the way. Any thoughts of self dought I will bring them here and get feedback from my brothers and sisters.
But I`m sure my body was starving for it I feel it`s happiness everyday.