i can testify that the changes, at least for me, were rather drastic. initially i was on a low intro dosage for the first two mths and had some blood work done as my physical developments were faster than what was expected, then it was upped. shortly after my mood swings got out of hand and i was emotionally unstable; this went on for abt two weeks and i had to have my hormone regimen changed. the new regimen, again, was on an intro dosage, which went on for a mth, and after that it was upped to my present dosage of fortnightly injections of 10mg depo-estradiol at my butt. i settled down on my new hormone regimen comfortably i guess after the change, and i was basically i had to change my pants and jeans every three mths for abt a year, just for an example. like what my therapist put it, i was practically blooming, and it has smtg to do with my genetic makeup.