Susan's Place Transgender Resources

We always are warned that blood coagulation-factor will/may get too high and causing risk of deep vain thrombosis when taking estradiol (HRT)

When ever I cut myself, even smaller skin scratches, I am bleeding  a LOT longer since on HRT.
For all I understand this should be just the other way around, the blood-clotting-factors goes high rather then low -> bleeding much longer.

I am not on WAFARIN (blood thinning drug) or some such, not even Baby-Aspirin which was all prescribed for me after I had a bypass op. one year ago.
I had to go back on "Inegy 10/20" (ezetimibe/simvastatin) due to very high cholesterol level of 7.2

So why would my blood clotting be so slow/low when on HRT (E + AA and some P)

Axelle

Its possible the foods you eat are the cause because some foods lower blood coagulation and others like fish increase it maybe try fix your nutrition levels in the food you eat and see if that helps.

You would need blood tests to properly determine blood clotting times.

This could be easily explained by thinner skin as a result of HRT.

Also depends on what HRT you're taking. Bioidentical HRT hasn't had too many implications for clotting problems.

Asfsd4214,

My last blood tests determined my clotting factor was low-ish but still just in range as I recall. (I put that down to being blood group O, which is said to be on the low side genetically)

Thinner skin, yes. That is a good point, given my age even more so? Will that make small cuts tend to bleed on and on, and creating bruises very quickly? Maybe...

I do use bioidentical E, - 17 beta-estradiol -, initially EstroFem (estradiol) and lately EstroPause (estradiol valerate), 3 tabs/day. Add Spiro and Fincar (generic Prepocia, Proscar, Finasteride) in the lowest MtF pre-op recommended doses. The former 1 tab/day and latter 1tab every second day, to it halve with no need to split tabs (being kind of tricky).

Also "clotting" as in getting DVT, is in my understanding if blood coagulates to readily, not the other way around as I preceive is my case.

Nothing much out of the ordinary, yes?

Axelle

Axelle,
  I only take two of those you mentioned plus progesterone.  My cuts clot quickly, except for the occasional nosebleed, the same as before.  It may be in your family history.  Stroke in my family does not exist, but cancer, MD, Alzheimer's and old age does!
  Joelene

If you are concerned it would be worth having a talk to your GP and having a coag blood test. Any changes since last time would show up straight away.

Karen.

It (coag factor) is low, as I finally found out, due to Simvastatin part of the combination cholesterol drug Inegy 10/20 (10mg ezetimibe and 20mg simvastatin) and not HRT, E2...

The main reason for it seems to be the following:

"Simvastatin depresses blood clotting..."

see: http://www.ncbi.nlm.nih.gov/pubmed/11342472 (http://www.ncbi.nlm.nih.gov/pubmed/11342472)

and: http://circ.ahajournals.org/content/103/18/2248.full (http://circ.ahajournals.org/content/103/18/2248.full)

Lipitor ... same story... just for good measure see:

http://www.ehealthme.com/ds/lipitor/coagulation+factor+decreased (http://www.ehealthme.com/ds/lipitor/coagulation+factor+decreased)


I also think a main reason for my getting brain haematoma last year...

->-bleeped-<-, ->-bleeped-<-, ->-bleeped-<-, I was digging this up as asked by my FFS surgeon to stop Simvastatin, as much as Aspirin, and a number of vitamin supplements - well I don't take any.

And as always ... YMMV,
Axélle

Quote from: Axélle on July 09, 2012, 01:04:18 AM
It (coag factor) is low, as I finally found out, due to Simvastatin part of the combination cholesterol drug Inegy 10/20 (10mg ezetimibe and 20mg simvastatin) and not HRT, E2...

The main reason for it seems to be the following:

"Simvastatin depresses blood clotting..."

see: http://www.ncbi.nlm.nih.gov/pubmed/11342472 (http://www.ncbi.nlm.nih.gov/pubmed/11342472)

and: http://circ.ahajournals.org/content/103/18/2248.full (http://circ.ahajournals.org/content/103/18/2248.full)

Lipitor ... same story... just for good measure see:

http://www.ehealthme.com/ds/lipitor/coagulation+factor+decreased (http://www.ehealthme.com/ds/lipitor/coagulation+factor+decreased)


I also think a main reason for my getting brain haematoma last year...

->-bleeped-<-, ->-bleeped-<-, ->-bleeped-<-, I was digging this up as asked by my FFS surgeon to stop Simvastatin, as much as Aspirin, and a number of vitamin supplements - well I don't take any.

And as always ... YMMV,
Axélle

I was on Simvastatin (Zocor), Plavix, and 81 mg aspirin (2x daily) for several years following 3-way bypass.

I ended up with brain bleeds.

A known side effect of Simvastatin is decreased coagulation. It is usually routinely monitored by your medic, or should be, particularly if you have a history. There are other anti-cholesterol drugs without coagulation effects, they operate through a different pathway. Rosuvastatin calcium, known as Crestor is one, I'm on this. It can have side effects on the liver. It an also induce memory loss but I cannot remember if that has happened to me.

Get checked immediately if you have a known history of bleeds.

Cindy

Quote from: Cindy James on July 09, 2012, 03:54:28 AM
A known side effect of Simvastatin is decreased coagulation. It is usually routinely monitored by your medic, or should be, particularly if you have a history. There are other anti-cholesterol drugs without coagulation effects, they operate through a different pathway. Rosuvastatin calcium, known as Crestor is one, I'm on this. It can have side effects on the liver. It an also induce memory loss but I cannot remember if that has happened to me.

Get checked immediately if you have a known history of bleeds.

Cindy

I DO --- bleeding on the BRAIN... subdural-haematoma, eish!

Also, using statins for some time (if older) ... cancer issues now being reported. Die of cancer or a heart attack - what a choice?

I take the latter (after 101 big O's)... yeeeeesss!

Let's find the dude who's gonna give me THAT coup de grace :)

Axélle

Quote from: Cindy James on July 09, 2012, 03:54:28 AM
Rosuvastatin calcium, known as Crestor is one, I'm on this. It can have side effects on the liver. It an also induce memory loss but I cannot remember if that has happened to me.

Cindy

Of course you wouldn't remember memory loss, that's the whole point! :D

More seriously, I think the rate of temporary memory loss on Crestor is about 1:500000 or something ridiculous, and it generally tends to be that you forget one day.  This is from what I heard from a cardiovascular professor a few years ago.   He basically said - Crestor reduces the rate of stroke from vascular disease by about 25%, and would personally rather take his chances of forgetting on day.

Oh I forgot that :laugh: :laugh: :laugh:

Seriously, when you are on medications get regular blood tests from your family medic. You need to be monitored over the long term. You will have peaks and troughs that alone mean nothing, but if you are getting a gradual, rise or fall in something that will (should) trigger a further investigation.  And that is a good thing not a bad thing. Sometimes we get a bit nervous that the Dr wants to see us for another test. A damn sight better than the undertaker wanting to have a measure.

Cindy