Community Conversation => Transitioning => Hormone replacement therapy => Topic started by: Amy1988 on April 01, 2015, 08:31:39 AM Return to Full Version
Title: Doing some math
Post by: Amy1988 on April 01, 2015, 08:31:39 AM
Post by: Amy1988 on April 01, 2015, 08:31:39 AM
Ok so I read that the liver metabolizes about 30% of the pill form estradiol. So if a person takes 2mg then by my calculations that would leave 1.4mg that survives the liver?
Title: Re: Doing some math
Post by: KayXo on April 01, 2015, 08:41:59 AM
Post by: KayXo on April 01, 2015, 08:41:59 AM
Bio-availability from pills is typically, on average, 5% so that only 5% of the estradiol swallowed will make it to the blood. I can PM you the various sources that cite this.
From 2 mg, you get 0.1 mg estradiol, similar to the 0.1 mg patch.
From 2 mg, you get 0.1 mg estradiol, similar to the 0.1 mg patch.
Title: Re: Doing some math
Post by: Amy1988 on April 01, 2015, 09:04:29 AM
Post by: Amy1988 on April 01, 2015, 09:04:29 AM
Quote from: Amy1988 on April 01, 2015, 08:31:39 AM
Ok so I read that the liver metabolizes about 30% of the pill form estradiol. So if a person takes 2mg then by my calculations that would leave 1.4mg that survives the liver?
Please send PM
Title: Re: Doing some math
Post by: ImagineKate on April 01, 2015, 09:44:42 AM
Post by: ImagineKate on April 01, 2015, 09:44:42 AM
I take it sublingually to avoid the liver pass.
Title: Re: Doing some math
Post by: Amy1988 on April 01, 2015, 09:48:34 AM
Post by: Amy1988 on April 01, 2015, 09:48:34 AM
Quote from: KayXo on April 01, 2015, 08:41:59 AM
Bio-availability from pills is typically, on average, 5% so that only 5% of the estradiol swallowed will make it to the blood. I can PM you the various sources that cite this.
From 2 mg, you get 0.1 mg estradiol, similar to the 0.1 mg patch.
What is the bioavailability of .6 mg estradiol gel?