Susan's Place Transgender Resources

The use of cultured autologous oral epithelial cells for vaginoplasty in male-to-female transsexuals: a feasibility, safety, and advantageousness clinical pilot study.

http://www.ncbi.nlm.nih.gov/pubmed/24374675

By Plastic Reconstruction Surgeons: Dessy LA, Mazzocchi M, Corrias F, Ceccarelli S, Marchese C, Scuderi N.
January 13, 2014

"he use of cultured autologous oral epithelium to cover the neovagina walls is presented."
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OP own words:This post is a follow-up to an article last year describing autologous grafting of laboratory-grown vaginas in females with congenital defects that required vaginal reconstruction. Bottom line:  It is now possible to for MtF transsexuals to have a self-lubricating mucosal membrane in neovaginas created by the penile inversion technique.  The cells are taken from the buccal lining of the mouth.  It isn't identical to an actual female vagina, but it's one step closer.

Mod Edit Note: Shortened the article synopsis to fit news article protocol.

Oooooh! Can't wait for this to be standard practice!

Hi there and thank you for posting this. Can you please include a link so the post can be modified for formatting?

Quote from: Maybebaby56 on May 22, 2015, 01:05:02 PM
This post is a follow-up to an article last year describing autologous grafting of laboratory-grown vaginas in females with congenital defects that required vaginal reconstruction. Bottom line:  It is now possible to for MtF transsexuals to have a self-lubricating mucosal membrane in neovaginas created by the penile inversion technique.  The cells are taken from the buccal lining of the mouth.  It isn't identical to an actual female vagina, but it's one step closer. 

Abstract: Summary: Various vaginoplasty methods in male-to-female transsexuals have been described, but none is ideal.  The use of cultured autologous oral epithelium to cover the neovagina walls is presented.  Six patients were operated on.  Complications encountered were one case of low-located rectovaginal fistula that was treated conservatively; one case of partial glans necrosis resulting in a scarred but sensitive clitoris; one case of large labia majora requiring redn.; and one case of short vagina requiring surgical revision with autologous cultured oral cells that was successful.  All patients had adequate vagina, experienced sexual intercourse, and were satisfied with results.  Autologous cultured oral epithelium transplantation is feasible, safe, and advantageous.  Satisfactory neovaginas were provided; the procedure is relatively easy to perform and provides a thin, mucosa-lined neovagina with a sufficient
amt. of secretion.

Plastic and Reconstructive Surgery
Volume133
Issue1
Pages158-161
Journal; Online Computer File
2014
CODEN:PRSUAS
ISSN:1529-4242
DOI:10.1097/01.prs.0000435844.95551.35

I think I can pull the link up. gimmie a sec

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How long should it take for this to become a common practice in GRS. When I get GRS, I want to be self-lubricating, but getting a piece of intestine removed to do so seems kind of extreme. Would be possible to this on women are already post-op?

Quote from: Echo Alcestis on May 23, 2015, 03:38:25 PM
couldnt find the link to this article. the link i found is super long i found the link a minute ago but this article is from 1 years ago. sry, made a mistake on the date lol. its from 2014

That's a good thing, not a bad thing. That's one less year we have to wait for this to become common practice.

Quote from: rachel89 on May 23, 2015, 03:18:14 PM
How long should it take for this to become a common practice in GRS. When I get GRS, I want to be self-lubricating, but getting a piece of intestine removed to do so seems kind of extreme. Would be possible to this on women are already post-op?

Shure, much like using colon technique vaginoplasty for revision surgeries today.

Quote from: rachel89 on May 23, 2015, 03:18:14 PM
How long should it take for this to become a common practice in GRS. When I get GRS, I want to be self-lubricating, but getting a piece of intestine removed to do so seems kind of extreme. Would be possible to this on women are already post-op?

Concerning lubrication you could have a look here:
https://www.susans.org/forums/index.php/topic,149304.msg1682002.html#msg1682002

hugs

WHOA! Thats blooming brilliant. I've just downloaded and read the paper and thats one of those, damn I wish I had thought of that ideas...

Having that as a student paper would have certainly made my medical reputation!

Thats is a genuinely genius idea.

One more reason I'm waiting 2-3 years for GRS!

Omg. That is amazing self lubrication isn't something I thought could happen so cool I want I want yes please

Quote from: jessica32 on August 08, 2015, 07:47:19 PM
Omg. That is amazing self lubrication isn't something I thought could happen so cool I want I want yes please

At this point I'm calling it.  In 10 years we'll have a nano-bot hive system that can increase/reduce bone mass based on educated estimates on how hormones may have effected a transgender patient, allowing them to have a body that better matches their identified gender.

Unfortunately, in my work as a medical research librarian I've seen this kicking around since at least 2011; I don't think anyone should hold their breath. (Though it *would* be amazing!)

Incidentally, plenty of women self-lubricate with the current techniques...

Quote from: Jenna Marie on August 23, 2015, 10:22:16 AM
Unfortunately, in my work as a medical research librarian I've seen this kicking around since at least 2011; I don't think anyone should hold their breath. (Though it *would* be amazing!)

Incidentally, plenty of women self-lubricate with the current techniques...

I'd say its the other way around... there are quite a few good things not yet put to use...

its like the gay marriages... many people would not have thought a few years ago...


hugs

Well for what its worth one of my friends and surgical colleagues (James Bellringer) does a lot of the UK surgery. I spoke to him about this... his view was that sadly it was not the golden result that it was supposed to be. There were longterm complications that developed and which were not noted in that paper. So his view was that he would not carry out this procedure. However he did tell me about other work that he and others are doing which has broadly the same aim, via a different technique, so while I suspect this one may not fly, there are other advances in the works. Cell culture is a powerful technique and we have only just begun to exploit it... watch this space.

Laura : Oh, I wasn't actually saying it wouldn't happen. I was saying it won't happen SOON. If it's pushing five years since this idea was out there, clearly progress is slow and application to trans women even slower. Personally, I decided I wanted a vagina immediately rather than wait for this to develop enough to be of use to me, and that was three years ago now.

Others with more medical expertise have addressed the fact that adapting it to trans women in specific would require an additional level of complication, and it's not even beyond the tentative experimental stage with cis girls, so my feeling is that it'll be quite a few more years before we see this technique available to us (if it is at all, since Jenny is now suggesting it might not work after all).

Gay marriage is actually a good comparison to me, because I also would not have suggested that someone who had the right to marry 10 years ago now in Massachusetts wait years and years to find out whether it'd be accepted nationwide; there's an opportunity cost to waiting, too. It means going without "good enough" for indefinite years waiting for "perfect." In both situations, people will judge the risk/benefit ratio differently, but in both cases it would have been foolish to assume that the "perfect" option would be available in a year or two.

Quote from: Rejennyrated on August 23, 2015, 11:36:37 AM
Well for what its worth one of my friends and surgical colleagues (James Bellringer) does a lot of the UK surgery. I spoke to him about this... his view was that sadly it was not the golden result that it was supposed to be. There were longterm complications that developed and which were not noted in that paper. So his view was that he would not carry out this procedure. However he did tell me about other work that he and others are doing which has broadly the same aim, via a different technique, so while I suspect this one may not fly, there are other advances in the works. Cell culture is a powerful technique and we have only just begun to exploit it... watch this space.

Like I said, nano-hiveminds built to gradually phase the body fully into the biological identity of what the person feels...It's coming, remember I said it!

QuoteLike I said, nano-hiveminds built to gradually phase the body fully into the biological identity of what the person feels...It's coming, remember I said it!

        God I hope you are right. When I was very young I daydreamed about being able to have an injection or something and waking up a year later having grown 'naturally' into the person that I should've been.

So this is about the four girls with MRKH? (http://www.iflscience.com/health-and-medicine/laboratory-grown-vaginas-succesfully-transplanted-patients) Here's a direct link to a video: https://www.youtube.com/watch?v=IHF-lIu5D_U

There does appear to be some hope for FtM (http://www.iflscience.com/health-and-medicine/laboratory-grown-penises-ready-be-tested-humans) parts as well since they're testing lab grown penises.

This article (http://hplusmagazine.com/2014/05/08/total-gender-change-within-decade/) has been the most interesting for me however. There are a few lines that sound pretty promising, like: "But researchers have already discovered how to tell ovaries to become testes." If that's the case then it'd be interesting if they could pump out their own hormones rather than needing them from external sources. Also, "We're also making progress at creating 'artificial' ovaries, and stem cells have been successfully used to give rabbits larger penises."

The article was from 2011, so there's been awhile since then. What I'd most like to see is a 3D printed vagina or a donated vagina washed in a detergent to leave only the extracellular matrix and lined with someone's own stem cells to create a properly functional vagina in all respects.

It is a little worrying though with the knowledge that testes could potentially one day be made to become ovaries because if removed, as tends to be the case with SRS, then it seems like that would no longer be possible.

I know this is a serious discussion, but all I saw was this:

Quote from: Venus on September 11, 2015, 06:55:57 PM
"Stem cells have been successfully used to give rabbits larger penises."

And I knew exactly who the target market was...
(https://www.susans.org/proxy.php?request=http%3A%2F%2Fwww.picgifs.com%2Fclip-art%2Fcartoons%2Fbugs-bunny%2Fclip-art-bugs-bunny-625373.jpg&hash=6134f0d9075a5f4c784f7824fb5505eba4ffdb97)

I'm all seriousness though it is great what strides are being taken with this new medical technology and I just hope I'll still be here when it becomes possible for a MTF to bear children.

I would never have thought that facial surgery and vocal surgery was possible when I did my thing. I'm very happy for those who wish to have those thngs done and get them.

As far as the gay marriage thing goes. Well, we've been able to get married for some time now in many states but equal rights for us lag at least a generation. I hope I'm wrong. But i'm seeing so many brave young women post on Facebook and youtube. It is getting the issue in front of the public. The more they see, the more accepting they shall become.

Cindi

Quote from: iKate on May 28, 2015, 10:07:36 AM
One more reason I'm waiting 2-3 years for GRS!

I want surgery by the end of 2016, but there are so many exciting advances on the horizon. I would hate to get it Dec. 2016 and then a few months later someone starts performing SRS using Lab Grown Vaginas.

Quote from: lisarenee on September 20, 2015, 04:22:44 PM

Quote from: iKate on May 28, 2015, 10:07:36 AM
One more reason I'm waiting 2-3 years for GRS!

I want surgery by the end of 2016, but there are so many exciting advances on the horizon. I would hate to get it Dec. 2016 and then a few months later someone starts performing SRS using Lab Grown Vaginas.

I doubt we'll see gender surgeons doing these procedures in the next few years. Maybe five years or so out but I, for one, am not inclined to wait that long.